Regulation of Nuclear Lamin Polymerization by Importin α
نویسندگان
چکیده
منابع مشابه
Regulation of Nuclear Lamin Polymerization by Importin
REGULATION OF NUCLEAR LAMIN POLYMERIZATION BY IMPORTIN Adam, Stephen A., Kaushik Sengupta, and Robert D. Goldman From Department of Cell and Molecular Biology Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 1 These authors contributed equally to this work. Address correspondence to Stephen A. Adam, Ph.D., W129 303 E. Chicago Avenue, Chicago IL 60611 Fax: 312-503-7...
متن کاملAcetylation of importin-α nuclear import factors by CBP/p300
Histone acetylases were originally identified because of their ability to acetylate histone substrates [1–3]. Acetylases can also target other proteins such as transcription factors [4–7]. We asked whether the acetylase CREB-binding protein (CBP) could acetylate proteins not directly involved in transcription. A large panel of proteins, involved in a variety of cellular processes, were tested a...
متن کاملNuclear importin α and its physiological importance
Importin α is recognized as a classical nuclear localization signal (cNLS) receptor which mediates nucleocytoplasmic transport. However, it rapidly accumulates in the nucleus in response to cellular stresses, including oxidative stress, causing a blockade of the classical nuclear import pathway. We set out to determine whether importin α performs roles in the nucleus after cellular exposure to ...
متن کاملRegulation of Nucleotide Excision Repair by Nuclear Lamin B1
The nuclear lamins play important roles in the structural organization and function of the metazoan cell nucleus. Recent studies on B-type lamins identified a requirement for lamin B1 (LB1) in the regulation of cell proliferation in normal diploid cells. In order to further investigate the function of LB1 in proliferation, we disrupted its normal expression in U-2 OS human osteosarcoma and othe...
متن کاملExport of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor
1996) and the KNS shuttling domain of the hnRNP K * Zentrum fü r Molekulare Biologie der protein, which allows both import and export (Michael Universitä t Heidelberg et al., 1997). 69120 Heidelberg A fundamental question is how it is possible for the Federal Republic of Germany shuttling transport receptors to carry their cargo in only † Abteilung Molekulare Biologie der Mitose one direction. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m709572200